Three Different Sequences of Events that Result in Inflammation or in the Enhancement of Inflammation

The inflammatory response is triggered whenever body tissues are injured by physical trauma, intense heat, irritating chemicals, or infection and begins when a flood of inflammatory chemicals are released into the extracellular fluid. Macrophages bear surface membrane receptors called Toll-like receptors (TLRs) that play a central role in triggering immune response. Each TLR is recognized for a specific class of attacking microbe. Once activated, a TLR triggers a release of cytokines that promote inflammation and attract WBCs.…