Angiopotein-1 Alongside VEGF Plays a Pivotal Role in Glomeruloid Body Formation

Previous investigations on glomeruloid bodies (GB) have focused on the action of VEGF. Recently it has come to light that VEGF alone in insufficient for tumour angiogenesis but involves a host of other factors. The Tie-2 receptor tyrosine kinase has been identified as the only other endothelium specific receptor and is activated through angiopoetin-1 (Ang-1). Tie-2 activation is shown to increase vessel branching, increased interaction of vessel tissue within itself and its surroundings and endothelial survival. …